RHOC Antibody

CAT: 0223-57-478Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-478Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
NCBI Gene ID
389
Swiss Prot
P08134
Accession Number
P08134
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
RHOC
NCBI Official Name
Rho-related GTP-binding protein RhoC
NCBI Organism
Homo sapiens
Background Reference 01
Jiang, L., et al. Int. J. Cancer 127 (3) :505-512 (2010)
Background Reference 02
Wu, M., et al. Cancer 116 (11 SUPPL), 2768-2782 (2010) :
Background Reference 03
Lipkin, S.M., et al. Cancer Prev Res (Phila) 3 (5) :597-603 (2010)
Background Reference 04
Kitzing, T.M., et al. Oncogene 29 (16) :2441-2448 (2010)
Other Product Names
Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC
Tested Applications
WB
Protein ID
132543
Physical Properties
Liquid

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