RHOC Antibody

• Background :

  This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

• NCBI Gene ID :

  389

• Swiss Prot :

  P08134

• Accession Number :

  P08134

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  22 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:2000

• Symbol :

  RHOC

• NCBI Official Name :

  Rho-related GTP-binding protein RhoC

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Jiang, L., et al. Int. J. Cancer 127 (3) :505-512 (2010)

• Background Reference 02 :

  Wu, M., et al. Cancer 116 (11 SUPPL), 2768-2782 (2010) :

• Background Reference 03 :

  Lipkin, S.M., et al. Cancer Prev Res (Phila) 3 (5) :597-603 (2010)

• Background Reference 04 :

  Kitzing, T.M., et al. Oncogene 29 (16) :2441-2448 (2010)

• Other Product Names :

  Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC

• Tested Applications :

  WB

• Protein ID :

  132543

• Physical Properties :

  Liquid