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UBE2D3 Antibody

CAT: 0223-58-731Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-731Size:400 µL
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Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
NCBI Gene ID
7323
Swiss Prot
P61077
Accession Number
P61077
Host
Rabbit
Reactivity
Human
Immunogen
This UBE2D3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-136 amino acids from the C-terminal region of human UBE2D3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Pig, Bovine, Monkey, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
17 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
UBE2D3
NCBI Official Name
Ubiquitin-conjugating enzyme E2 D3
NCBI Organism
Homo sapiens
Background Reference 01
Kalsi, G., et al. Hum. Mol. Genet. 19 (12) :2497-2506 (2010)
Background Reference 02
Wu, K., et al. Mol. Cell 37 (6) :784-796 (2010)
Background Reference 03
Vina-Vilaseca, A., et al. J. Biol. Chem. 285 (10) :7645-7656 (2010)
Background Reference 04
Markson, G., et al. Genome Res. 19 (10) :1905-1911 (2009)
Other Product Names
Ubiquitin-conjugating enzyme E2 D3, Ubiquitin carrier protein D3, Ubiquitin-conjugating enzyme E2 (17) KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3, UBE2D3, UBC5C, UBCH5C
Tested Applications
WB
Protein ID
46577654
Physical Properties
Liquid

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