ACSL3 Antibody

• Background:

  The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.

• NCBI Gene ID:

  2181

• Swiss Prot:

  O95573

• Accession Number:

  O95573

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ACSL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 528-556 amino acids from the C-terminal region of human ACSL3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  80 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ACSL3

• NCBI Official Name:

  Long-chain-fatty-acid--CoA ligase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Weedon-Fekjaer, M.S., et al. J. Lipid Res. 51 (7) :1886-1896 (2010)

• Background Reference 02:

  Cao, A., et al. J. Biol. Chem. 285 (22) :16664-16674 (2010)

• Background Reference 03:

  Perera, F., et al. PLoS ONE (2), E4488 (2009) :

• Background Reference 04:

  Yao, H., et al. J. Biol. Chem. 283 (2) :849-854 (2008)

• Other Product Names:

  Long-chain-fatty-acid--CoA ligase 3, Long-chain acyl-CoA synthetase 3, LACS 3, ACSL3, ACS3, FACL3, LACS3

• Tested Applications:

  WB

• Physical Properties:

  Liquid