ACSL4 Antibody

• Background:

  The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.

• NCBI Gene ID:

  2182

• Swiss Prot:

  O60488

• Accession Number:

  O60488

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ACSL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human ACSL4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  79 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ACSL4

• NCBI Official Name:

  Long-chain-fatty-acid--CoA ligase 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bosker, F.J., et al. Mol. Psychiatry (2010) In press :

• Background Reference 02:

  Zhang, Y., et al. Hum. Mol. Genet. 18 (20) :3894-3905 (2009)

• Background Reference 03:

  Zeman, M., et al. Tohoku J. Exp. Med. 217 (4) :287-293 (2009)

• Background Reference 04:

  An, C., et al. Neurosci. Lett. 441 (2) :197-200 (2008)

• Other Product Names:

  Long-chain-fatty-acid--CoA ligase 4, Long-chain acyl-CoA synthetase 4, LACS 4, ACSL4, ACS4, FACL4, LACS4

• Tested Applications:

  WB

• Physical Properties:

  Liquid