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HNRNPD Antibody

CAT: 0223-58-256Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-256Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) . These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
NCBI Gene ID
3184
Swiss Prot
Q14103
Accession Number
Q14103
Host
Rabbit
Reactivity
Human
Immunogen
This HNRNPD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human HNRNPD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Symbol
HNRNPD
NCBI Official Name
Heterogeneous nuclear ribonucleoprotein D0
NCBI Organism
Homo sapiens
Background Reference 01
Ishimaru, D., et al. J. Biol. Chem. 285 (35) :27182-27191 (2010)
Background Reference 02
Zhai, B., et al. J. Biol. Chem. 285 (31) :23568-23580 (2010)
Background Reference 03
Vazquez-Chantada, M., et al. Gastroenterology 138 (5) :1943-1953 (2010)
Background Reference 04
Trojanowicz, B., et al. Endocr. Relat. Cancer 16 (3) :857-871 (2009)
Other Product Names
Heterogeneous nuclear ribonucleoprotein D0, hnRNP D0, AU-rich element RNA-binding protein 1, HNRNPD, AUF1, HNRPD
Tested Applications
WB, IF
Protein ID
13124489
Physical Properties
Liquid

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