Mouse TLR1 Antibody

• Background :

  Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs) . DCs can incorporate pathogens, produce a variety of cytokines, maturate, and present pathogen-derived peptides to T cells, thereby inducing T cell activation and differentiation. These responses are triggered by microbial recognition through type I transmembrane proteins, Toll-like receptors (TLRs) on DCs. TLRs consist of ten members and each TLR is involved in recognizing a variety of microorganism-derived molecular structures. TLR ligands include cell wall components, proteins, nucleic acids, and synthetic chemical compounds, all of which can activate DCs as immune adjuvants. Each TLR can activate DCs in a similar, but distinct manner. For example, TLRs can be divided into subgroups according to their type I interferon (IFN) inducing ability. TLR2 cannot induce IFN-alpha or IFN-beta, but TLR4 can lead to IFN-beta production. Meanwhile, TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. Recent evidences suggest that cytoplamic adapters for TLRs are especially crucial for this functional heterogeneity.

• NCBI Gene ID :

  21897

• Swiss Prot :

  Q9EPQ1

• Accession Number :

  Q9EPQ1

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This Mouse TLR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 764-795 amino acids from the C-terminal region of mouse TLR1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  91 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  Tlr1

• NCBI Official Name :

  Toll-like receptor 1

• NCBI Organism :

  Mus musculus

• Background Reference 01 :

  Hajjar, A.M., et al., J. Immunol. 166 (1) :15-19 (2001) .

• Background Reference 02 :

  Ozinsky, A., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (25) :13766-13771 (2000) .

• Other Product Names :

  Toll-like receptor 1, Toll/interleukin-1 receptor-like protein, TIL, CD281, Tlr1

• Tested Applications :

  WB, IHC-P

• Physical Properties :

  Liquid