SEC61B Antibody

• Background:

  The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.

• NCBI Gene ID:

  10952

• Swiss Prot:

  P60468

• Accession Number:

  P60468

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SEC61B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the Central region of human SEC61B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  10 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SEC61B

• NCBI Official Name:

  Protein transport protein Sec61 subunit beta

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liao, H.J., et al. Cancer Res. 69 (15) :6179-6183 (2009)

• Background Reference 02:

  Wang, B., et al. Cell 133 (6) :1080-1092 (2008)

• Background Reference 03:

  Liao, H.J., et al. Mol. Biol. Cell 18 (3) :1064-1072 (2007)

• Background Reference 04:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Other Product Names:

  Protein transport protein Sec61 subunit beta, SEC61B

• Tested Applications:

  WB, IHC-P

• Protein ID:

  42560366

• Physical Properties:

  Liquid