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Mouse Akt1 Antibody

CAT: 0223-57-924Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-924Size:400 µL
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Background
This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
11651
Swiss Prot
P31750
Accession Number
P31750
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Akt1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-49 amino acids from the N-terminal region of mouse Akt1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Human
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Symbol
Akt1
NCBI Official Name
RAC-alpha serine/threonine-protein kinase
NCBI Organism
Mus musculus
Background Reference 01
Chang, Z., et al. Dev. Biol. 347 (2) :384-391 (2010)
Background Reference 02
Zhou, F., et al. Am. J. Pathol. 177 (4) :2124-2133 (2010)
Background Reference 03
Sun, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (39) :16887-16892 (2010)
Background Reference 04
Goncalves, M.D., et al. PLoS ONE (9), E12707 (2010) :
Other Product Names
RAC-alpha serine/threonine-protein kinase, AKT1 kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, Thymoma viral proto-oncogene, Akt1, Akt, Rac
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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