Mouse Epha2 Antibody

• Background:

  Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity) . Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.

• NCBI Gene ID:

  13836

• Swiss Prot:

  Q03145

• Accession Number:

  Q03145

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Epha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the Central region of mouse Epha2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  109 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Epha2

• NCBI Official Name:

  Ephrin type-A receptor 2

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Islam, S., et al. Dig. Dis. Sci. 55 (9) :2478-2488 (2010)

• Background Reference 02:

  Kim, J., et al. Mol. Cell. Biol. 30 (7) :1582-1592 (2010)

• Background Reference 03:

  Zirzow, S., et al. Dev. Biol. 336 (2) :145-155 (2009)

• Background Reference 04:

  Jun, G., et al. PLoS Genet. (7), E1000584 (2009) :

• Other Product Names:

  Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Epha2, Eck, Myk2, Sek2

• Tested Applications:

  WB

• Physical Properties:

  Liquid