PSMA1 Antibody

• Background :

  The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• NCBI Gene ID :

  5682

• Swiss Prot :

  P25786

• Accession Number :

  P25786

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This PSMA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 234-262 amino acids from the C-terminal region of human PSMA1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  30 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  PSMA1

• NCBI Official Name :

  Proteasome subunit alpha type-1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Zhang, Y., et al. Biochem. Biophys. Res. Commun. 355 (1) :245-251 (2007)

• Background Reference 02 :

  Apcher, G.S., et al. FEBS Lett. 569 (1-3), 211-216 (2004) :

• Background Reference 03 :

  Jayarapu, K., et al. Biochem. Biophys. Res. Commun. 314 (2) :523-528 (2004)

• Background Reference 04 :

  Apcher, G.S., et al. FEBS Lett. 553 (1-2), 200-204 (2003) :

• Other Product Names :

  Proteasome subunit alpha type-1, 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, PSMA1, HC2, NU, PROS30, PSC2

• Tested Applications :

  WB

• Protein ID :

  130848

• Physical Properties :

  Liquid