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PSMA1 Antibody

CAT: 0223-57-838Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-838Size:400 µL
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Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
5682
Swiss Prot
P25786
Accession Number
P25786
Host
Rabbit
Reactivity
Human
Immunogen
This PSMA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 234-262 amino acids from the C-terminal region of human PSMA1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PSMA1
NCBI Official Name
Proteasome subunit alpha type-1
NCBI Organism
Homo sapiens
Background Reference 01
Zhang, Y., et al. Biochem. Biophys. Res. Commun. 355 (1) :245-251 (2007)
Background Reference 02
Apcher, G.S., et al. FEBS Lett. 569 (1-3), 211-216 (2004) :
Background Reference 03
Jayarapu, K., et al. Biochem. Biophys. Res. Commun. 314 (2) :523-528 (2004)
Background Reference 04
Apcher, G.S., et al. FEBS Lett. 553 (1-2), 200-204 (2003) :
Other Product Names
Proteasome subunit alpha type-1, 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, PSMA1, HC2, NU, PROS30, PSC2
Tested Applications
WB
Protein ID
130848
Physical Properties
Liquid

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