PSMF1 Antibody

• Background:

  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.

• NCBI Gene ID:

  9491

• Swiss Prot:

  Q92530

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-271 of human PSMF1 (NP_006805.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  SW480

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 35kDa

• Fragment:

  IgG

• Symbol:

  PSMF1

• Positive Control 2:

  A-549

• Positive Control 3:

  Mouse liver

• Positive Control 4:

  Mouse testis

• NCBI Official Name:

  Proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PSMF1, proteasome (prosome, macropain) inhibitor subunit 1 (PI31), PI31, RP4-545L17.1, proteasome inhibitor hP131 subunit, proteasome inhibitor subunit 1

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid