RIPK3 Antibody

• Background:

  The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

• NCBI Gene ID:

  11035

• Swiss Prot:

  Q9Y572

• Accession Number:

  Q9Y572

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the C-terminal region of human RIPK3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RIPK3

• NCBI Official Name:

  Receptor-interacting serine/threonine-protein kinase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Background Reference 02:

  Vandenabeele, P., et al. Sci Signal (115), RE4 (2010) :

• Background Reference 03:

  Cho, Y.S., et al. Cell 137 (6) :1112-1123 (2009)

• Background Reference 04:

  He, S., et al. Cell 137 (6) :1100-1111 (2009)

• Other Product Names:

  Receptor-interacting serine/threonine-protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  205371831

• Physical Properties:

  Liquid