Products for Research Use Only
RegisterLogin

RIPK1 Antibody

CAT: 0223-3291-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-3291-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
NCBI Gene ID
8737
Swiss Prot
Q13546
Accession Number
NP_003795
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
RIPK1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Buffer
RIPK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RIPK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 74 kDa
Fragment
IgG
Symbol
RIPK1
NCBI Official Name
Receptor (TNFRSF) -interacting serine-threonine kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Stanger BZ, Leder P, Lee TH, et al. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 1995; 81:513-23.
Background Reference 02
Hsu H, Huang J, Shu HB, et al. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 1996; 4:387-96.
Background Reference 03
Meylan E, Burns K, Hofmann K, et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat. Immunol.; 2004; 5:503-7.
Background Reference 04
Festjens N, Vanden Bergh T, Cornelis S, et al. RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ. 2007;14:400-10.
Other Product Names
RIPK1 Antibody: RIP, RIP1, RIP, Cell death protein RIP, RIP-1
Tested Applications
ELISA, IHC-P
Protein ID
57242761
Physical Properties
Liquid

Related Products

CatalogName
3291PRIPK1 Peptide
5389PRIPK1 Peptide
26-084RIPK4 Antibody
63-216RIPK3 Antibody
57-813RIPK3 Antibody
27-361RIPK3 Antibody
23-623RIPK4 Antibody
14-522RIPK4 Antibody
64-160WAS Antibody
60-596WAS Antibody

Alternative Products

CatalogName
70R-21675RIPK1 antibody

Popular Products