RPS19 Antibody

• Background:

  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

• NCBI Gene ID:

  6223

• Swiss Prot:

  P39019

• Accession Number:

  P39019

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RPS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the C-terminal region of human RPS19.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  16 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RPS19

• NCBI Official Name:

  40S ribosomal protein S19

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Devlin, E.E., et al. Blood 116 (15) :2826-2835 (2010)

• Background Reference 02:

  Iadevaia, V., et al. Oncogene 29 (40) :5490-5499 (2010)

• Background Reference 03:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04:

  Nishiura, H., et al. Apoptosis 15 (8) :966-981 (2010)

• Other Product Names:

  40S ribosomal protein S19, RPS19

• Tested Applications:

  WB

• Protein ID:

  730640

• Physical Properties:

  Liquid