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RPS19 Antibody

CAT: 0223-57-801Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-801Size:400 µL
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Background
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
NCBI Gene ID
6223
Swiss Prot
P39019
Accession Number
P39019
Host
Rabbit
Reactivity
Human
Immunogen
This RPS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the C-terminal region of human RPS19.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
16 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RPS19
NCBI Official Name
40S ribosomal protein S19
NCBI Organism
Homo sapiens
Background Reference 01
Devlin, E.E., et al. Blood 116 (15) :2826-2835 (2010)
Background Reference 02
Iadevaia, V., et al. Oncogene 29 (40) :5490-5499 (2010)
Background Reference 03
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 04
Nishiura, H., et al. Apoptosis 15 (8) :966-981 (2010)
Other Product Names
40S ribosomal protein S19, RPS19
Tested Applications
WB
Protein ID
730640
Physical Properties
Liquid

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