PHLDA2 Antibody

• Background:

  This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

• NCBI Gene ID:

  7262

• Swiss Prot:

  Q53GA4

• Accession Number:

  Q53GA4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PHLDA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the C-terminal region of human PHLDA2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  17 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PHLDA2

• NCBI Official Name:

  Pleckstrin homology-like domain family A member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19 (21) :4296-4303 (2010)

• Background Reference 02:

  Edenberg, H.J., et al. Alcohol. Clin. Exp. Res. 34 (5) :840-852 (2010)

• Background Reference 03:

  Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

• Background Reference 04:

  Tang, K.F., et al. Biochim. Biophys. Acta 1770 (5) :820-825 (2007)

• Other Product Names:

  Pleckstrin homology-like domain family A member 2, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein, Imprinted in placenta and liver protein, Tumor-suppressing STF cDNA 3 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein, p17-Beckwith-Wiedemann region 1 C, p17-BWR1C, PHLDA2, BWR1C, HLDA2, IPL, TSSC3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  84029394

• Physical Properties:

  Liquid