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PCDHB1 Antibody

CAT: 0223-57-732Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-732Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
NCBI Gene ID
29930
Swiss Prot
Q9Y5F3
Accession Number
Q9Y5F3
Host
Rabbit
Reactivity
Human
Immunogen
This PCDHB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 782-811 amino acids from the C-terminal region of human PCDHB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
90 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PCDHB1
NCBI Official Name
Protocadherin beta-1
NCBI Organism
Homo sapiens
Background Reference 01
Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :
Background Reference 02
Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)
Background Reference 03
Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)
Background Reference 04
Yagi, T., et al. Genes Dev. 14 (10) :1169-1180 (2000)
Other Product Names
Protocadherin beta-1, PCDH-beta-1, PCDHB1
Tested Applications
WB
Protein ID
205371811
Physical Properties
Liquid

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