PCDHB12 Antibody

• Background:

  This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

• NCBI Gene ID:

  56124

• Swiss Prot:

  Q9Y5F1

• Accession Number:

  Q9Y5F1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PCDHB12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 766-795 amino acids from the C-terminal region of human PCDHB12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  87 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PCDHB12

• NCBI Official Name:

  Protocadherin beta-12

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :

• Background Reference 02:

  Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)

• Background Reference 03:

  Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)

• Background Reference 04:

  Yagi, T., et al. Genes Dev. 14 (10) :1169-1180 (2000)

• Other Product Names:

  Protocadherin beta-12, PCDH-beta-12, PCDHB12

• Tested Applications:

  WB, IHC-P

• Protein ID:

  13431382

• Physical Properties:

  Liquid