CCDC50 Antibody

• Background:

  This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF) -mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].

• NCBI Gene ID:

  152137

• Swiss Prot:

  Q8IVM0

• Accession Number:

  Q8IVM0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CCDC50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human CCDC50.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  36 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CCDC50

• NCBI Official Name:

  Coiled-coil domain-containing protein 50

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Farfsing, A., et al. Leukemia 23 (11) :2018-2026 (2009)

• Background Reference 02:

  Kameda, H., et al. Biochem. Biophys. Res. Commun. 378 (4) :744-749 (2009)

• Background Reference 03:

  Bohgaki, M., et al. Biochim. Biophys. Acta 1783 (5) :826-837 (2008)

• Background Reference 04:

  Modamio-Hoybjor, S., et al. Am. J. Hum. Genet. 80 (6) :1076-1089 (2007)

• Other Product Names:

  Coiled-coil domain-containing protein 50, Protein Ymer, CCDC50, C3orf6

• Tested Applications:

  WB, IHC-P

• Protein ID:

  73619722

• Physical Properties:

  Liquid