ADAM11 Antibody

• Background:

  This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq].

• NCBI Gene ID:

  4185

• Swiss Prot:

  O75078

• Accession Number:

  O75078

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ADAM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the N-terminal region of human ADAM11.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  83 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:500

• Symbol:

  ADAM11

• NCBI Official Name:

  Disintegrin and metalloproteinase domain-containing protein 11

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fu, G.K., et al. Genomics 84 (1) :205-210 (2004)

• Background Reference 02:

  Hillman, R.T., et al. Genome Biol. (2), R8 (2004) :

• Background Reference 03:

  Shea, S.H., et al. Behav. Genet. 31 (2) :231-239 (2001)

• Background Reference 04:

  Sagane, K., et al. Biochem. J. 334 (PT 1), 93-98 (1998) :

• Other Product Names:

  Disintegrin and metalloproteinase domain-containing protein 11, ADAM 11, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein, MDC, ADAM11, MDC

• Tested Applications:

  WB

• Physical Properties:

  Liquid