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BAG2 Antibody

CAT: 0223-57-448Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-448Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq].
NCBI Gene ID
9532
Swiss Prot
O95816
Accession Number
O95816
Host
Rabbit
Reactivity
Human
Immunogen
This BAG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the C-terminal region of human BAG2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Symbol
BAG2
NCBI Official Name
BAG family molecular chaperone regulator 2
NCBI Organism
Homo sapiens
Background Reference 01
Arndt, V., et al. Mol. Biol. Cell 16 (12) :5891-5900 (2005)
Background Reference 02
Dai, Q., et al. J. Biol. Chem. 280 (46) :38673-38681 (2005)
Background Reference 03
Ueda, K., et al. J. Biol. Chem. 279 (40) :41815-41821 (2004)
Background Reference 04
Ueda, K., et al. J. Biol. Chem. 279 (40) :41815-41821 (2004)
Other Product Names
BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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