BAG2 Antibody

• Background :

  BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq].

• NCBI Gene ID :

  9532

• Swiss Prot :

  O95816

• Accession Number :

  O95816

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This BAG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the C-terminal region of human BAG2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  24 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  BAG2

• NCBI Official Name :

  BAG family molecular chaperone regulator 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Arndt, V., et al. Mol. Biol. Cell 16 (12) :5891-5900 (2005)

• Background Reference 02 :

  Dai, Q., et al. J. Biol. Chem. 280 (46) :38673-38681 (2005)

• Background Reference 03 :

  Ueda, K., et al. J. Biol. Chem. 279 (40) :41815-41821 (2004)

• Background Reference 04 :

  Ueda, K., et al. J. Biol. Chem. 279 (40) :41815-41821 (2004)

• Other Product Names :

  BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2

• Tested Applications :

  WB, IHC-P

• Physical Properties :

  Liquid