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AVPR1B Antibody

CAT: 0223-57-446Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-446Size:400 µL
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Background
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.
NCBI Gene ID
553
Swiss Prot
P47901
Accession Number
P47901
Host
Rabbit
Reactivity
Human
Immunogen
This AVPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 289-317 amino acids from the C-terminal region of human AVPR1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AVPR1B
NCBI Official Name
Vasopressin V1b receptor
NCBI Organism
Homo sapiens
Background Reference 01
Van West, D., et al. Psychiatry Res 179 (1) :64-68 (2010)
Background Reference 02
Binder, E.B., et al. Arch. Gen. Psychiatry 67 (4) :369-379 (2010)
Background Reference 03
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :
Background Reference 04
Van West, D., et al. Psychiatr. Genet. 19 (2) :102-103 (2009)
Other Product Names
Vasopressin V1b receptor, V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor, AVPR1B, AVPR3, VPR3
Tested Applications
WB
Protein ID
1351392
Physical Properties
Liquid

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