CEACAM3 Antibody

• Background:

  This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

• NCBI Gene ID:

  1084

• Swiss Prot:

  P40198

• Accession Number:

  P40198

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CEACAM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the C-terminal region of human CEACAM3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  27 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CEACAM3

• NCBI Official Name:

  Carcinoembryonic antigen-related cell adhesion molecule 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Tsavaris, N., et al.Chemother 21 (6) :673-680 (2009)

• Background Reference 03:

  Skubitz, K.M., et al.Transl Med 6, 78 (2008) :

• Background Reference 04:

  Stern-Ginossar, N., et al. J. Immunol. 179 (7) :4424-4434 (2007)

• Other Product Names:

  Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1, CD66d, CEACAM3, CD66D, CGM1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  218511974

• Physical Properties:

  Liquid