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SF3B1 Antibody

CAT: 0223-57-247Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-247Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP) . The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
NCBI Gene ID
23451
Swiss Prot
O75533
Accession Number
O75533
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SF3B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-402 amino acids from the N-terminal region of human SF3B1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
146 kDa
Fragment
Rabbit Ig
Symbol
SF3B1
NCBI Official Name
Splicing factor 3B subunit 1
NCBI Organism
Homo sapiens
Background Reference 01
Corsini, L., et al. J. Biol. Chem. 284 (1) :630-639 (2009)
Background Reference 02
Tanuma, N., et al. J. Biol. Chem. 283 (51) :35805-35814 (2008)
Background Reference 03
Pessa, H.K., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (25) :8655-8660 (2008)
Background Reference 04
Kuwasako, K., et al. Proteins 71 (4) :1617-1636 (2008)
Other Product Names
Splicing factor 3B subunit 1, Pre-mRNA-splicing factor SF3b 155 kDa subunit, SF3b155, Spliceosome-associated protein 155, SAP 155, SF3B1, SAP155
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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