SYT1 Antibody

• Background:

  The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]) .

• NCBI Gene ID:

  6857

• Swiss Prot:

  P21579

• Accession Number:

  P21579

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SYT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the C-terminal region of human SYT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Monkey, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SYT1

• NCBI Official Name:

  Synaptotagmin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Musch, M.W., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (2), G203-G211 (2010) :

• Background Reference 03:

  Kathir, K.M., et al. Biochim. Biophys. Acta 1798 (2) :297-302 (2010)

• Background Reference 04:

  Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :

• Other Product Names:

  Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT

• Tested Applications:

  WB, IHC-P

• Protein ID:

  135086

• Physical Properties:

  Liquid