Products for Research Use Only
RegisterLogin

FOLH1 Antibody

CAT: 0223-57-212Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-57-212Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
NCBI Gene ID
2346
Swiss Prot
Q04609
Accession Number
Q04609
Host
Rabbit
Reactivity
Human
Immunogen
This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the N-terminal region of human FOLH1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
84 kDa
Fragment
Rabbit Ig
Symbol
FOLH1
NCBI Official Name
Glutamate carboxypeptidase 2
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Giusti, B., et al. Thromb. Haemost. 104 (2) :231-242 (2010)
Background Reference 03
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Background Reference 04
Mlcochova, P., et al. Prostate 69 (5) :471-479 (2009)
Other Product Names
Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, FOLH1, FOLH, NAALAD1, PSM, PSMA
Tested Applications
WB, IHC-P, IF
Protein ID
548615
Physical Properties
Liquid

Related Products

CatalogName
11-262PSMA / FOLH1 Recombinant Protein
11-228PSMA / FOLH1 Recombinant Protein
10-663Pasotuxizumab (CD3E/FOLH1) - Research Grade Biosimilar
10-136Huj591-Gsmab (FOLH1/PSMA) - Research Grade Biosimilar
55-347FOLR1 Antibody
96-795FOLR1 Recombinant Protein
96-995FOLR1 Recombinant Protein
10-757Mirvetuximab (FOLR1) - Research Grade Biosimilar
10-308Farletuzumab (FOLR1) - Research Grade Biosimilar
64-160WAS Antibody

Alternative Products

CatalogName
10R-6952FOLH1 antibody

Popular Products