BNIP3 Antibody

• Background:

  NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

• NCBI Gene ID:

  664

• Swiss Prot:

  Q12983

• Accession Number:

  Q12983

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This BNIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-187 amino acids from human BNIP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Autophagy

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BNIP3

• NCBI Official Name:

  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  References for protein:

• Background Reference 02:

  Kothari, S., et al., Oncogene 22 (30) :4734-4744 (2003) .

• Background Reference 03:

  Lee, S.M., et al., Life Sci. 71 (19) :2267-2277 (2002) .

• Background Reference 04:

  Ray, R., et al., J. Biol. Chem. 275 (2) :1439-1448 (2000) .

• Other Product Names:

  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BNIP3, NIP3

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  20532402

• Physical Properties:

  Liquid