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SUMO4 Antibody

CAT: 0223-56-566Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-566Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
NCBI Gene ID
387082
Swiss Prot
Q6EEV6
Accession Number
Q6EEV6
Host
Rabbit
Reactivity
Human
Immunogen
This SUMO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 amino acids from human SUMO4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
11 kDa
Fragment
Rabbit Ig
Symbol
SUMO4
NCBI Official Name
Small ubiquitin-related modifier 4
NCBI Organism
Homo sapiens
Background Reference 01
Park, Y., et al. Nat. Genet. 37 (2), 112 (2005)
Background Reference 02
Guo, D., et al. Nat. Genet. 36 (8), 837-841 (2004)
Background Reference 03
Bohren, K.M., et al. J. Biol. Chem. 279 (26), 27233-27238 (2004)
Background Reference 04
Yang, S.H., et al., Mol. Cell 13 (4) :611-617 (2004) .
Other Product Names
Small ubiquitin-related modifier 4, SUMO-4, Small ubiquitin-like protein 4, SUMO4, SMT3H4
Tested Applications
WB, IHC-P
Protein ID
81175019
Physical Properties
Liquid

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