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TMEM43 Antibody

CAT: 0223-56-541Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-541Size:400 µL
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Background
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) . Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.
NCBI Gene ID
79188
Swiss Prot
Q9BTV4
Accession Number
Q9BTV4
Host
Rabbit
Reactivity
Human
Immunogen
This TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Symbol
TMEM43
NCBI Official Name
Transmembrane protein 43
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Barahona-Dussault, C., et al. Clin. Genet. 77 (1) :37-48 (2010)
Background Reference 03
Hodgkinson, K., et al. Genet. Med. 11 (12) :859-865 (2009)
Background Reference 04
Merner, N.D., et al. Am. J. Hum. Genet. 82 (4) :809-821 (2008)
Other Product Names
Transmembrane protein 43, Protein LUMA, TMEM43
Tested Applications
WB, IHC-P
Protein ID
74733151
Physical Properties
Liquid

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