NDUFS8 Antibody

• Background :

  This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.

• NCBI Gene ID :

  4728

• Swiss Prot :

  O00217

• Accession Number :

  O00217

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This NDUFS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the Central region of human NDUFS8.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, C. Elegans, Monkey, Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  24 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  NDUFS8

• NCBI Official Name :

  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) Bourges, I., et al. Biochem. J. 383 (PT 3), 491-499 (2004) Procaccio, V., et al. Neurology 62 (10) :1899-1901 (2004) Ugalde, C., et al. Hum. Mol. Genet. 13 (6) :659-667 (2004) Murray, J., et al. J. Biol. Chem. 278 (39) :37223-37230 (2003)

• Other Product Names :

  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial, Complex I-23kD, CI-23kD, NADH-ubiquinone oxidoreductase 23 kDa subunit, TYKY subunit, NDUFS8

• Tested Applications :

  WB, IHC-P

• Physical Properties :

  Liquid