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WFDC1 Antibody

CAT: 0223-56-449Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-449Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.
NCBI Gene ID
58189
Swiss Prot
Q9HC57
Accession Number
Q9HC57
Host
Rabbit
Reactivity
Human
Immunogen
This WFDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-177 amino acids from the C-terminal region of human WFDC1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Symbol
WFDC1
NCBI Official Name
WAP four-disulfide core domain protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Briggs, F.B., et al. Genes Immun. 11 (3) :199-208 (2010)
Background Reference 02
Madar, S., et al. Carcinogenesis 30 (1) :20-27 (2009)
Background Reference 03
Liu, S., et al. Clin. Exp. Metastasis 26 (7) :739-749 (2009)
Background Reference 04
Alvarez, R., et al. J. Virol. 82 (1) :471-486 (2008)
Other Product Names
WAP four-disulfide core domain protein 1, Prostate stromal protein ps20, ps20 growth inhibitor, WFDC1, PS20
Tested Applications
WB, IHC-P, Flow
Protein ID
22096244
Physical Properties
Liquid

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