WFDC2 Antibody

CAT: 0223-7459-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7459-01Size:0.02 mg
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Background
The WAP four-disulfide core domain protein 2 (WFDC2), also known as epididymal protein 4, is a member of the WFDC domain family, a family of proteins that is characterized by the presence of Whey Acidic Protein (WAP) domain, and is highly expressed in the lung and salivary gland (1,2) . Members of this family include SLPI and elafin, antiproteinases involved in the innate immune system (2) . WFDC2 has been proposed to play a critical role in tumor formation and growth in ovarian cancer cells through the regulation of growth- and apoptosis-associated genes and may thus be a potential therapeutic target for epithelial ovarian cancer (3) .
NCBI Gene ID
10406
Swiss Prot
Q14508
Accession Number
NP_006094
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
WFDC2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 - A549 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rabbit: (73%)
Buffer
WFDC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
WFDC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
WFDC2 antibody is human specific. Multiple isoforms of WFDC2 are known to exist.
Symbol
WFDC2
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
WAP four-disulfide core domain 2
NCBI Organism
Homo sapiens
Background Reference 01
Drapkin R, von Horsten HH, Lin Y, et al. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serious and endometrioid ovarian carcinomas. Cancer Res. 2005; 65:2162-9.
Background Reference 02
Bingle L, Cross SS, High AS, et al. WFDC2 (HE4) : A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Resp. Res. 2006; 7:61.
Background Reference 03
Chen Y, Mu X, Wang S, et al. WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncol. Rep. 2013; 29:288-96.
Other Product Names
WFDC2 Antibody : HE4, WAP5, EDDM4, dJ461P17.6, HE4, WAP four-disulfide core domain protein 2, Epididymal secretory protein E4
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
56699495
Physical Properties
Liquid

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