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MYBPC3 Antibody

CAT: 0223-56-426Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-426Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.
NCBI Gene ID
4607
Swiss Prot
Q14896
Accession Number
Q14896
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This MYBPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
141 kDa
Fragment
Rabbit IgG
Symbol
MYBPC3
NCBI Official Name
Myosin-binding protein C, cardiac-type
NCBI Organism
Homo sapiens
Background Reference 01
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Millat, G., et al. EurMed Genet 53 (5) :261-267 (2010)
Background Reference 04
Zimmerman, R.S., et al. Genet. Med. 12 (5) :268-278 (2010)
Other Product Names
Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3
Tested Applications
WB, IHC-P
Protein ID
425906074
Physical Properties
Liquid

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