MYBPC2 Antibody

CAT: 0223-5651-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-5651-01Size:0.02 mg
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Background
MYBPC2 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the fast-type isoform designated MYBPC2. Both the fast-type and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. MYBPC2 is typically required for strong contractions and functions under anaerobic conditions. It is more similar to the cardiac isoform (MYBPC3) than to the slow-type isoform (MYBPC1) in terms of pCa50-indexed force development, length-independent cooperativity and length dependent activation. It has been suggested that in cardiac and fast muscle MYBPC2 contributes to an internal load, possibly by binding to actin via its N-terminal region.
NCBI Gene ID
4606
Swiss Prot
Q14324
Accession Number
EAW71866
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
MYBPC2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (91%)
Buffer
MYBPC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MYBPC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
MYBPC2
NCBI Official Name
Myosin binding protein C, fast type
NCBI Organism
Homo sapiens
Background Reference 01
Weber FE, Vaughan KT, Reiach FC, et al. Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C) . Differential expression, conserved domain structure and chromosome assignment. Eur. J. Biochem.1993; 216:661-9.
Background Reference 02
Konhilas JP, Irving TC and De Tombe PP. Length-dependent activation in three striated muscle types of the rat. J. Physiol.2002; 544:225-36.
Background Reference 03
Flashman E, Korkie L, Watkins H, et al. Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle. FEBS Lett.2008; 582:434-8.
Other Product Names
MYBPC2 Antibody: MYBPC, MYBPCF, Myosin-binding protein C, fast-type, C-protein, skeletal muscle fast isoform, Fast MyBP-C
Tested Applications
ELISA, WB, IHC-P
Protein ID
119592272
Physical Properties
Liquid

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