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CYP5A1 Antibody

CAT: 0223-56-215Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-215Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
6916
Swiss Prot
P24557
Accession Number
P24557
Host
Rabbit
Reactivity
Mouse
Immunogen
This CYP5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-257 amino acids from the Central region of human CYP5A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
61 kDa
Fragment
Rabbit Ig
Symbol
TBXAS1
NCBI Official Name
Thromboxane-A synthase
NCBI Organism
Homo sapiens
Background Reference 01
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 02
Wang, L.H., et al. Prostaglandins Other Lipid Mediat. 68-69, 409-422 (2002) :
Background Reference 03
Tazawa, R., et al. Arch. Biochem. Biophys. 334 (2) :349-356 (1996)
Background Reference 04
Baek, S.J., et al. Gene 173 (2) :251-256 (1996)
Other Product Names
Thromboxane-A synthase, TXA synthase, TXS, Cytochrome P450 5A1, TBXAS1, CYP5, CYP5A1
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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