CASP12 Antibody

CAT: 0223-56-185Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-185Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
NCBI Gene ID
100506742
Swiss Prot
Q6UXS9
Accession Number
Q6UXS9
Host
Rabbit
Reactivity
Human
Immunogen
This CASP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human CASP12.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Symbol
CASP12
NCBI Official Name
Inactive caspase-12
NCBI Organism
Homo sapiens
Background Reference 01
Lee, H.J., et al. Arch. Biochem. Biophys. 502 (1) :68-73 (2010)
Background Reference 02
Plantinga, T.S., et al. J. Acquir. Immune Defic. Syndr. 55 (1) :87-94 (2010)
Background Reference 03
McCall, M.B., et al. Eur. Cytokine Netw. 21 (2) :77-83 (2010)
Background Reference 04
Kachapati, K., et al. Hum. Mutat. 27 (9), 975 (2006) :
Other Product Names
Inactive caspase-12, CASP-12, CASP12
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
395398427
Physical Properties
Liquid

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