CASP12 Antibody

• Background :

  Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

• NCBI Gene ID :

  100506742

• Swiss Prot :

  Q6UXS9

• Accession Number :

  Q6UXS9

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CASP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human CASP12.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle, Obesity, Neuroscience

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  39 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CASP12

• NCBI Official Name :

  Inactive caspase-12

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Lee, H.J., et al. Arch. Biochem. Biophys. 502 (1) :68-73 (2010)

• Background Reference 02 :

  Plantinga, T.S., et al. J. Acquir. Immune Defic. Syndr. 55 (1) :87-94 (2010)

• Background Reference 03 :

  McCall, M.B., et al. Eur. Cytokine Netw. 21 (2) :77-83 (2010)

• Background Reference 04 :

  Kachapati, K., et al. Hum. Mutat. 27 (9), 975 (2006) :

• Other Product Names :

  Inactive caspase-12, CASP-12, CASP12

• Tested Applications :

  WB, IHC-P, IF, Flow

• Protein ID :

  395398427

• Physical Properties :

  Liquid