CD8B1 Antibody

• Background:

  The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

• NCBI Gene ID:

  926

• Swiss Prot:

  P10966

• Accession Number:

  P10966

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-167 amino acids from the C-terminal region of human CD8B1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CD8B

• NCBI Official Name:

  T-cell surface glycoprotein CD8 beta chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Chen, M.L., et al. Eur. J. Immunol. 39 (12) :3423-3435 (2009)

• Background Reference 03:

  Thakral, D., et al. J. Immunol. 180 (11) :7431-7442 (2008)

• Background Reference 04:

  Stove, V., et al. J. Virol. 79 (17) :11422-11433 (2005)

• Other Product Names:

  T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1

• Tested Applications:

  WB

• Protein ID:

  116032

• Physical Properties:

  Liquid