HSP90B1 Antibody

• Background:

  HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]) .

• NCBI Gene ID:

  7184

• Swiss Prot:

  P14625

• Accession Number:

  P14625

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HSP90B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 460-487 amino acids from the Central region of human HSP90B1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  92 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HSP90B1

• NCBI Official Name:

  Endoplasmin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Suzuki, S., et al. Biochem. Biophys. Res. Commun. 398 (3) :525-531 (2010)

• Background Reference 03:

  Bloor, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (15) :6970-6975 (2010)

• Background Reference 04:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Other Product Names:

  Endoplasmin, 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, GRP94, TRA1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  119360

• Physical Properties:

  Liquid