CYP1A2 Antibody

• Background:

  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

• NCBI Gene ID:

  1544

• Swiss Prot:

  P05177

• Accession Number:

  P05177

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CYP1A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-282 amino acids from the Central region of human CYP1A2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CYP1A2

• NCBI Official Name:

  Cytochrome P450 1A2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gentile, G., et al.Headache Pain 11 (5) :431-435 (2010) Uslu, A., et al. BMB Rep 43 (8) :530-534 (2010) Wang, X., et al. J. Pharm. Pharmacol. 62 (8) :1077-1083 (2010) Schmidt, R.J., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (7) :560-569 (2010) Jiang, Z., et al. Pharmacogenet. Genomics 16 (5) :359-367 (2006)

• Other Product Names:

  Cytochrome P450 1A2, CYPIA2, Cytochrome P (3) 450, Cytochrome P450 4, Cytochrome P450-P3, CYP1A2

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  117144

• Physical Properties:

  Liquid