THEMIS Antibody

• Background:

  This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  387357

• Swiss Prot:

  Q8N1K5

• Accession Number:

  Q8N1K5

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This THEMIS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 559-588 amino acids from the C-terminal region of human THEMIS.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  73 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  THEMIS

• NCBI Official Name:

  Protein THEMIS

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Dubois, P.C., et al. Nat. Genet. 42 (4) :295-302 (2010)

• Background Reference 03:

  Bhatti, P., et al. Radiat. Res. 173 (2) :214-224 (2010)

• Background Reference 04:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Other Product Names:

  Protein THEMIS, Thymocyte-expressed molecule involved in selection, THEMIS, C6orf190, C6orf207

• Tested Applications:

  WB, IHC-P

• Protein ID:

  150421530

• Physical Properties:

  Liquid