Vimentin Antibody

• Background:

  Vimentin is the major protein subunit of the 10nm or intermediate filaments (IFs) found in many kinds of mesenchymal and epithelial cells as well as developing neuronal and astrocytic precursor cells in the CNS. Vimentin is thought to be critically involved in lymphocyte adhesion and transmigration (Nieminen M et al. 2006) . Copolymers are frequently formed between vimentin and other IFs, such as GFAP (in many kinds of astrocytes), desmin (in muscle cells) and neurofilament proteins (in developing neurons) . Antibodies to vimentin are useful in studies of stem cells and generally to reveal the filamentous cytoskeleton. Recent studies suggest that vimentin affects prostate cancer cells motility and invasiveness (Zhao et al. 2008) .

• NCBI Gene ID:

  7431

• Swiss Prot:

  P08670

• Accession Number:

  P08670

• Host:

  Chicken

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant human Vimentin purified from E. coli.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell, Cancer

• Purification:

  Total IgY fraction

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Vimentin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  50

• Specificity:

  Specific for the ~50kDa Vimentin protein.

• Symbol:

  VIM

• NCBI Official Name:

  Vimentin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nieminen M, Henttinen T, Merinen M, Marttila-Ichihara F, Eriksson JE, Jalkanen S (2006) Vimentin function in lymphocyte adhesion and transcellular migration. Nat Cell Biol 8 (2) :156-62.

• Background Reference 02:

  Zhao Y, Yan Q, Long X, Chen X, Wang Y (2008) Vimentin affects the mobility and invasiveness of prostate cancer cells. Cell Biochem Funct. May 8

• Tested Applications:

  WB, IHC

• Protein ID:

  55977767

• Physical Properties:

  Liquid