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Sirtuin 1 Antibody

CAT: 0223-36-283Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-36-283Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sirtuin-1 is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Sirtuin-1 emerged as critical regulator of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. Sirtuin-1 has been suggested as potential biomarker for tumorigenesis.
NCBI Gene ID
23411
Swiss Prot
Q96EB6
Accession Number
7657575
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human sirtuin 1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Innate Immunity, Obesity
Concentration
1 mg/ml
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Specificity
Recognizes human sirtuin 1. Detects a band of ~78kDa by Western blot.
Applications Notes
ELISA: (direct and indirect: 1:2,000-1:5,000) . Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.
Symbol
SIRT1
NCBI Official Name
Sirtuin 1
NCBI Organism
Homo sapiens
Other Product Names
SIRT1; NAD-dependent Deacetylase Sirtuin-1; SIR2-like Protein 1; SIR2L1
Tested Applications
ELISA, WB
Protein ID
NP_001135970.1
Physical Properties
Liquid

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