FOXP3 Antibody

• Background:

  FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) ; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.

• NCBI Gene ID:

  20371

• Swiss Prot:

  Q99JB6

• Accession Number:

  16905075

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  Recombinant mouse FOXP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -20˚ C.

• Specificity:

  Recognizes mouse FOXP3. Detects a band of ~46-49kDa by Western blot.

• Applications Notes:

  ELISA: (direct and indirect: 1:2,000-1:10,000) . Western Blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.

• Symbol:

  Foxp3

• NCBI Official Name:

  Forkhead box P3

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Forkhead Box Protein P3; Scurfin

• Tested Applications:

  ELISA, WB

• Protein ID:

  NP_473380.1

• Physical Properties:

  Liquid