BTLA Antibody [6F4]

• Background:

  B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

• NCBI Gene ID:

  151888

• Swiss Prot:

  Q7Z6A9

• Accession Number:

  145580621

• Host:

  Rat

• Reactivity:

  Human

• Immunogen:

  Ectodomain of human BTLA fused to human IgG Fc.

• Clonality:

  Monoclonal

• Clone:

  6F4

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Immunology, Innate Immunity

• Purification:

  >95% (SDS-PAGE)

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. In PBS containing 10% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG1

• Specificity:

  Recognizes human BTLA.

• Applications Notes:

  Immunohistochemistry: (frozen sections) .

• Symbol:

  BTLA

• NCBI Official Name:

  B and T lymphocyte associated

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  B and T Lymphocyte Associated; Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3

• Tested Applications:

  ELISA, Flow, Functional Assays

• Protein ID:

  NP_861445

• Physical Properties:

  Liquid