BTLA Antibody

• Background:

  The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1) . Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2) . Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3) .

• NCBI Gene ID:

  151888

• Swiss Prot:

  Q7Z6A9

• Accession Number:

  NP_861445

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  BTLA Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  BTLA Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  BTLA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.

• Symbol:

  BTLA

• Positive Control 2:

  Cat. No. 11-801 - Human Small Intestine Tissue Slide

• NCBI Official Name:

  B and T lymphocyte associated

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Carreno BM and Collins M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003; 24:524-7.

• Background Reference 02:

  Kobayashi Y, Iwata A, Suzuki K, et al. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. USA 2013; 110:5121-6.

• Background Reference 03:

  Lin SC, Kuo CC, and Chan CH. Association of a BTLA gene polymorphism with a risk of rheumatoid arthritis. J. Biomed. Sci. 2006; 13:853-60.

• Other Product Names:

  BTLA Antibody : BTLA1, CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  145580621

• Physical Properties:

  Liquid