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BTLA Antibody

CAT: 0223-7473-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7473-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1) . Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2) . Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3) .
NCBI Gene ID
151888
Swiss Prot
Q7Z6A9
Accession Number
NP_861445
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
BTLA Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Buffer
BTLA Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BTLA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.
Symbol
BTLA
Positive Control 2
Cat. No. 11-801 - Human Small Intestine Tissue Slide
NCBI Official Name
B and T lymphocyte associated
NCBI Organism
Homo sapiens
Background Reference 01
Carreno BM and Collins M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003; 24:524-7.
Background Reference 02
Kobayashi Y, Iwata A, Suzuki K, et al. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. USA 2013; 110:5121-6.
Background Reference 03
Lin SC, Kuo CC, and Chan CH. Association of a BTLA gene polymorphism with a risk of rheumatoid arthritis. J. Biomed. Sci. 2006; 13:853-60.
Other Product Names
BTLA Antibody : BTLA1, CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
145580621
Physical Properties
Liquid

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