CTRP6 Antibody [256-E]

• Background:

  CTRP6 mediates the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in skeletal muscle cells, subsequently mediating glycogen accumulation and fatty acid oxidation. It induces the expression of the potent anti-inflammatory cytokine IL-10 in macrophages. CTRP6 may be a potential serum marker for hepatocellular carcinoma, contributing to tumor angiogenesis by activating the Akt pathway. CTRP6 was also shown to be associated with obesity, type 1 diabetes mellitus (T1D), vitiligo (depigmentation of the skin) and ASFV (African Swine Fever Virus) . CTRP6 forms homotrimers and higher-order oligomers and it may also form heteromeric complexes with CTRP1. May be involved in kidney inflammation.

• NCBI Gene ID:

  114904

• Swiss Prot:

  Q9BXI9

• Accession Number:

  37181873

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human CTRP6 (globular domain-less) .

• Clonality:

  Monoclonal

• Clone:

  256-E

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Innate Immunity, Obesity

• Concentration:

  0.5 mg/ml

• Buffer:

  Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG1, kappa

• Specificity:

  Recognizes the N-terminal half of human CTRP6 full-length protein. Detects bands of ~16kDa and ~32kDa by Western blot.

• Applications Notes:

  ELISA: (direct or indirect: 1:200-1:500) . Immunohistochemistry (paraffin sections) : 1:200. Western blot: (1:200-1:500 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature) . Optimal conditions should be determined individually for each application.

• Symbol:

  C1QTNF6

• NCBI Official Name:

  C1q and tumor necrosis factor related protein 6

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Complement C1q Tumor Necrosis Factor-related Protein 6; C1QTNF6; C1qTNF-related Protein 6; ZACRP 6

• Tested Applications:

  ELISA, WB

• Protein ID:

  AAQ88740

• Physical Properties:

  Liquid