FGF-23 Antibody [FG322-3]

• Background:

  FGF-23 is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC) .

• NCBI Gene ID:

  8074

• Swiss Prot:

  Q9GZV9

• Accession Number:

  10190674

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human FGF-23.

• Clonality:

  Monoclonal

• Clone:

  FG322-3

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG1, kappa

• Specificity:

  Recognizes human FGF-23. Does not cross-react with mouse FGF-23.

• Applications Notes:

  ELISA: (direct and indirect: 1:2,000-1:5,000) . Immunohistochemistry: (paraffin sections (1:100-1:500) ) . Western Blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.

• Symbol:

  FGF23

• NCBI Official Name:

  Fibroblast growth factor 23

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Fibroblast Growth Factor 23; Tumor-derived Hypophosphatemia-inducing Factor

• Tested Applications:

  ELISA, IHC, WB

• Protein ID:

  NP_065689.1

• Physical Properties:

  Liquid