ERCC8 Antibody

• Background:

  This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.

• NCBI Gene ID:

  1161

• Swiss Prot:

  Q13216

• Accession Number:

  Q13216

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ERCC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of human ERCC8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ERCC8

• NCBI Official Name:

  DNA excision repair protein ERCC-8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)

• Background Reference 02:

  Guillem, V.M., et al. Am. J. Hematol. 85 (7) :482-486 (2010)

• Background Reference 03:

  Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :

• Background Reference 04:

  Kamenisch, Y., et al. J. Exp. Med. 207 (2) :379-390 (2010)

• Other Product Names:

  DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA, ERCC8, CKN1, CSA

• Tested Applications:

  WB, IHC-P

• Protein ID:

  3121917

• Physical Properties:

  Liquid