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ERCC8 Antibody

CAT: 0223-55-526Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-526Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
NCBI Gene ID
1161
Swiss Prot
Q13216
Accession Number
Q13216
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ERCC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of human ERCC8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
ERCC8
NCBI Official Name
DNA excision repair protein ERCC-8
NCBI Organism
Homo sapiens
Background Reference 01
Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)
Background Reference 02
Guillem, V.M., et al. Am. J. Hematol. 85 (7) :482-486 (2010)
Background Reference 03
Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 04
Kamenisch, Y., et al. J. Exp. Med. 207 (2) :379-390 (2010)
Other Product Names
DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA, ERCC8, CKN1, CSA
Tested Applications
WB, IHC-P
Protein ID
3121917
Physical Properties
Liquid

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