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E2F2 Antibody

CAT: 0223-55-208Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-208Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq].
NCBI Gene ID
1870
Swiss Prot
Q14209
Accession Number
Q14209
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This E2F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-286 amino acids from the Central region of human E2F2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
E2F2
NCBI Official Name
Transcription factor E2F2
NCBI Organism
Homo sapiens
Background Reference 01
Revenko, A.S., et al. Mol. Cell. Biol. 30 (22) :5260-5272 (2010)
Background Reference 02
Hayami, S., et al. Mol. Cancer 9, 59 (2010) :
Background Reference 03
Chen, J., et al. Cancer Causes Control 20 (9) :1769-1777 (2009)
Background Reference 04
Cunningham, J.M., et al. Br. J. Cancer 101 (8) :1461-1468 (2009)
Other Product Names
Transcription factor E2F2, E2F-2, E2F2
Tested Applications
WB
Protein ID
2494228
Physical Properties
Liquid

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