MALT1 Antibody [SPM578]

• Background:

  Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT-1) is found in extranodal low-grade B cell lymphomas. The gene encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT-1 gene and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18) (q21; q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT-1 caspase-like domain. MALT-1 mRNA is found in pre-B cells, mature B cells and plasma cells.

• NCBI Gene ID:

  10892

• Swiss Prot:

  Q9UDY8

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Amino acids 701-808 from the human protein were used as the immunogen for this MALT1 antibody.

• Clonality:

  Monoclonal

• Clone:

  SPM578

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Applications Notes:

  1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

• Symbol:

  MALT1

• NCBI Official Name:

  Mucosa associated lymphoid tissue lymphoma translocation gene 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1

• Tested Applications:

  Flow, IF, WB, IHC

• Physical Properties:

  Liquid