Desmin Antibody [DES/1711]

• Background:

  Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

• NCBI Gene ID:

  1674

• Swiss Prot:

  P17661

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat, Hamster, Chicken

• Immunogen:

  Recombinant human Desmin was used as the immunogen for the Desmin antibody.

• Clonality:

  Monoclonal

• Clone:

  DES/1711

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  DES

• NCBI Official Name:

  Desmin

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Desmin, DES

• Tested Applications:

  WB, Flow, IF, IHC-P

• Physical Properties:

  Liquid